Multiple endocrine neoplasia

MEN type 1

Parathyroid hyperplasia, pancreatic endocrine tumours, pituitary adenoma.

MEN type 2

Medullary carcinoma of thyroid (100%), phaeochromocytoma (50%).
Mutation in ret proto-oncogene: autosomal dominant.

Type 2A (Sipple's syndrome)

Parathyroid hyperplasia.

Type 2B (Schimke's syndrome)

Marfanoid habitus, characteristic facies, mucosal neuromas.
Failure to thrive, recurrent ileus, toxic megacolon, slipped femoral epiphyses.