POEMS syndrome

= peripheral neuropathy, organomegaly, endocrinopathy, monoclonal paraprotein, skin lesions
= Crow-Fukase syndrome
= Takatsuki's syndrome
= PEP (polyneuropathy, endocrinopathy, plasma-cell dyscrasia)

Epidemiology

Most common in Japan.

Clinical features

Main differential is SLE.

Treatment

High dose steroids (e.g., prednisolone 60mg od). Azathioprine and cyclophosphamide have been used.