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Peptic ulcers

Ulcers caused by gastric acid erosion.

Causes

Helicobacter pylori Aspirin

Presentation

Dyspepsia. Haematemesis.

Pathophysiology

Infection type 1: infection affects antrum → ↓pH → ↑ gastric acid secretion → duodenal ulcers and gastric mucosal metaplasia

Infection type 2: pangastritis → atrophic gastritis → gastric ulcers & Ca

Diagnosis

Urea breath test. Endoscopy.

Treatment

Triple therapy: omeprazole, amoxycillin, metronidazole.