Transplantation

HLA typing

Patients may become sensitised to HLA antigens by:

  1. Pregnancy
  2. Previous transplant
  3. Blood transfusion

Statistics

Demand in UK is >80 per million population. Transplant activity is 28 per million population.

Kidney graft survival t½:

Living Donor kidney transplantation

Advantages:
  1. Better outcome for recipient
  2. Lack of cadaveric donor organs
  3. optimal timing
Disadvantages:
  1. Mortality (0.03%)
  2. Morbidity (wound pain, hypertension, proteinuria)
  3. Inconvenience (>6/52 recovery period)
  4. Coercion (living unrelated needs to be approved by ULTRA)
  5. Untreatable condition found
Work-up (takes 3–6 months):