Alosetron

= Lotronex

Indications

Diarrhoea predominant IBS (abd pain + diarrhoea 12/52 in preceding 12/12).
1 mg o.d.

Mechanism

5HT3 receptor antagonist which increases colonic transit time.

Adverse effects

Constipation (28%), ischaemic colitis.

Contraindications

Evidence

Clinical trials showed 20% efficacy over placebo.