Drug: Bupropion

= Amfebutamone

Indications

Smoking cessation

Dose

Start 1/52 before intended quit date. Continue for 7/52 post quit date.
Best results: motivated + nicotine patches + regular counselling.

Evidence

Jorenby et al. NEJM 1999; 340: 685–91.

Study 2: N=893. Randomised, double-blind, placebo-controlled trial. Continuous 12/12 abstinence rates:
5.6% placebo
9.8% nicotine patch
18.4% bupropion
22.5% bupropion + nicotine patch

Unwanted effects

Insomnia (42%), dry mouth (11%), seizures (0.1%).

Contra-indications

Epilepsy, increased risk of seizures (head trauma, diabetics treated with hypoglycaemics; patients treated with stimulants, theophylline, antipsychotics, antidepressants). MAOI including selegiline. Pregnancy, anorexia nervosa, bipolar disorder.