Start 1/52 before intended quit date.
Continue for 7/52 post quit date.
Best results: motivated + nicotine patches + regular counselling.
Jorenby et al. NEJM 1999; 340: 685–91.
Study 2: N=893. Randomised, double-blind, placebo-controlled trial.
Continuous 12/12 abstinence rates:
9.8% nicotine patch
22.5% bupropion + nicotine patch
Insomnia (42%), dry mouth (11%), seizures (0.1%).
Epilepsy, increased risk of seizures (head trauma, diabetics treated with
hypoglycaemics; patients treated with stimulants, theophylline,
antipsychotics, antidepressants). MAOI including selegiline.
Pregnancy, anorexia nervosa, bipolar disorder.