HOPE trial

Yusuf et al. NEJM 2000;342:145-153.

Randomised controlled trial. N=9297. Ramapril vs. placebo.

Patients selected were at high risk of cardiovascular disease and/or stroke. (known angina, diabetes, peripheral vascular disease + ↑GP, ↑cholesterol, smoking)
Patients with heart failure or low ejection fraction were excluded.

Statistically significant decline in