Glycoprotein IIb/IIIa inhibitors
Abciximab (chimaeric human/murine Fab fragment)
(NICE September 2000)
- unstable angina (recurrent chest pain,
transient ST elevation, raised troponin,
haemodynamic instability, post-MI)
- non-Q wave MI
Mode of administration
Continuous intravenous infusion.
Concurrent aspirin + low dose unfractionated heparin.
- Bleeding (esp. intracranial)
Unstable angina: PRISM trial: NNT 11 at 30/7 (outcome death or AMI).
PTCA: EPIC, EPISTENT, CAPTURE trials.
Additional £17 million/year + additional cost of troponin testing.