Tacrolimus

Macrolide (Streptomyces tsukubaensis).

Indications

Kidney, liver transplant.

Method of administration

PO. IV associated with anaphylaxis.

Mechanism

Binds calcineurin and hence inhibits synthesis of IL-2 & IFNγ.

Adverse effects

Nephrotoxicity, hepatotoxicity, myelosuppresion.
CNS: headache, intention tremor, paraesthesia.
GI: Diarrhoea. CVS: hypertension.
Derm: hirsutism. Back pain.
↑glucose, ↑K+