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Tamoxifen

Indications

Adjuvant therapy in breast cancer. Best effect in ER+ tumours. Treatment in ER– tumours is controversial.

Method of Administration

For 5 years: Fisher B et al. J Natl Cancer Inst 1996;88:1529-42.

Mechanism

Oestrogen-receptor blocker→inhib. expr. of oestrogen regulated genes. Primarily a cytostatic agent.

Adverse effects

Menopausal symptoms, esp. in premenopausal women.
↑risk of endometrial carcinoma (partial oestrogen effect).

Evidence

Reduces recurrence and death.
Effective palliation in combination with chemotherapy..