Adjuvant therapy in breast cancer. Best effect in ER+ tumours.
Treatment in ER– tumours is controversial.
Method of Administration
For 5 years: Fisher B et al. J Natl Cancer Inst 1996;88:1529-42.
Oestrogen-receptor blocker→inhib. expr. of oestrogen regulated genes.
Primarily a cytostatic agent.
Menopausal symptoms, esp. in premenopausal women.
↑risk of endometrial carcinoma (partial oestrogen effect).
Reduces recurrence and death.
Effective palliation in combination with chemotherapy..