Hypertension, stable angina, Prinzmetal's angina, Raynaud's phenomenon.
Ca++ channel blocker. Main effect is in reducing peripheral
Also reduces myocardial contractility (negatively inotropic, ↓work of heart).
Conventional liquid filled capsules should no longer be used.
Only use extended release tablets once daily.
Most are negatively inotropic and worsen heart failure
(except amlodipine—PRAISE study).
Dependent oedema (10–30%) disappears on lying flat, not affected by diuretics,
hypotension, syncope (dose dependent).